Colloquium: What is a second-generation p-value, and why should you care?

Jeffrey Blume, PhD, University of Virginia
ZSR Auditorium. Tuesday, February 6th 11:00am

Despite decades of controversy, p-values remain a popular tool for assessing when the data are incompatible with the null hypothesis. While it is widely recognized that p-values are imperfect, the consequences of ignoring their flaws remain elusive and p-values continue to flourish in the scientific literature. In this talk, I will introduce the second-generation p-value, a novel and intuitive tool that better serves the intended purpose. I will illustrate their use in several examples, including a high-dimensional genomics setting, and show how their implicit emphasis on scientific relevance leads to improved statistical performance ( as measured by error rates and false discovery rates) and yields a better assessment of scientific relevance.